Genetic & Immunological Aspects of Diabetes
It is believed that a large proportion of cases of type 1 diabetes result from the autoimmune destruction of the pancreatic β cells. Genetic marker that makes person susceptible to diabetes is located on chromosome 6, and it’s an HLA (human leukocyte antigen) complex. Several HLA complexes have been connected to type 1 diabetes, and if the people have one or more of those, may develop type 1diabities. Fulminant type 1 diabetes (FT1D) is a novel subtype of type 1 diabetes characterized by extremely rapid onset and complete deficiency of insulin due to the destruction of pancreatic β cells. It has been proposed that locally produced MCP-1 may be involved in the development of diabetic nephropathy
A study also suggests that diabetes might be linked to genetics. To date, numerous mutations have been shown to affect type 2 diabetes risks. Genes associated with type 2 diabetes are:
- TCF7L2, which affects insulin secretion and glucose production
- ABCC8, which helps regulate insulin
- CAPN10, which is associated with type 2 diabetes risk in Mexican-Americans
- GLUT2, which helps move glucose into the pancreas
- GCGR, a glucagon hormone involved in glucose regulation
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Genetic & Immunological Aspects of Diabetes Conference Speakers
Recommended Sessions
- Adolescent Diabetes
- Biomarker: Diagnostic tool for Diabetes
- Clinical Research and Clinical Trials
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- Diabetes and Endocrine System
- Diabetes Physiology & Pathophysiology
- Diabetic Case Studies/reports
- Diagnostics approaches and Clinical Analysis
- Genetic & Immunological Aspects of Diabetes
- Innovations in Diabetes Care and Management
- Insulin Resistance and Prediabetes
- Metabolism and Obesity
- Nutrition Therapy of Diabetes
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